The Houston Texans were already facing adversity before Friday's practice.  The offense has been a dud through six games, and everyone is frustrated. Then to further complicate things, Nico Collins and Christian Kirk - their two most reliable receivers - missed practice Friday and were ruled out for Sunday's game when the Texans (2-4) host the San Francisco 49ers (5-2).

The Houston Texans will be without star wide receiver Nico Collins for Sunday's Week 8 matchup against the 49ers.

The Texans ruled out two of their top wide receivers. Nico Collins (concussion) and Christian Kirk (hamstring) will not play. Neither player practiced this week. Kirk has played only three games this season. Collins was injured in the fourth quarter of Monday night's loss to the Seahawks. The Texans also ruled out cornerback Alijah Huzzie (knee).

Houston Texans wide receivers Nico Collins and Christian Kirk have missed two straight practices on Wednesday and Thursday.

Houston Texans wide receiver Nico Collins' status for Week 8 is uncertain after he left Monday's 27-19 loss to the Seattle Seahawks with a concussion.

Aaron Wilson is an award-winning Texans and NFL reporter for KPRC 2 and www.click2houston.com. He has covered the NFL since 1997, including previous stints for The Houston Chronicle and The Baltimore Sun. This marks his 10th year covering the Texans after previously covering a Super Bowl winning team in Baltimore.

Collins (concussion) isn't practicing Friday, DJ Bien-Aime of ESPN.com reports. That also applies to Christian Kirk (hamstring), and with the duo also having missed practice Wednesday and Thursday, both players could be ruled out for Sunday's game against the 49ers later Friday.

The Houston Texans lost big Monday night out at Lumen Field against the Seattle Seahawks and not just on the field with a lack of an offensive identity