Adrenal steroidogenesis is under the control of the hypothalamic–pituitary–adrenal (HPA) axis. Furthermore, metabolic factors including insulin and obesity-related signals may play a role in ...

Principal amongst these is the discrepancy between the sensitivity of both steroidogenesis and cAMP production to ACTH in the adrenal cell. The concentration of ACTH required to produce a response ...

The role of insulin in the regulation of enzymes involved in adrenal steroidogenesis has been postulated, although much remains to be investigated, since not all women with PCOS show evidence of ...