Cytochrome P450 Defects Linked to Opioid Regimen Efficacy Most patients with multiple defects of the cytochrome P450 system naturally gravitated toward an opioid regimen primarily metabolized through ...

There is wide variability in the response of individuals to standard doses of antipsychotic drugs. It has been suggested that this may be partly explained by differences in the cytochrome P450 (CYP450 ...

Cytochrome P450 (CYP450), is a family of hemoglobin-coupled monooxygenases. In mammals, CYP450 oxidizes steroids, fatty acids, and xenobiotics, playing an important role in the metabolism of various ...

The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified in ...

Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...

Aim: The present study aimed to investigate the human genetic diversity of the CYP450 superfamily in order to identify functional interethnic differences and analyze the role of CYP450 enzymes in ...

Please provide your email address to receive an email when new articles are posted on . The majority of drug interactions today are attributed to the cytochrome P450 (CYP450) isoenzyme system. However ...

To characterize the metabolism of nuciferine by P450 enzymes and uridine diphosphate glucuronosyltransferase (UGT) in liver microsomes from humans and several other animals including rats, mice, dogs, ...

The superfamily of proteins called cytochrome P450 (CYP) enzymes are involved in the synthesis and metabolism of a range of internal and external cellular components. These enzymes have been ...

A number of studies have highlighted that ethnicity is an important factor influencing the genetic variability of some CYP450 enzymes and that human adaptation could have a role in shaping the genetic ...