The initiation of the innate immune responses relies on the detection of microbes by multiple pattern recognition receptors. Among these receptors, cyclic GMP-AMP synthase (cGAS) has been identified ...
The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) axis constitutes a central pathway in the detection of cytosolic DNA and the initiation of innate immune programmes. Upon ...
THE biologic role of cyclic AMP (adenosine 3′,5′-monophosphate), at least as it is understood today, is shown in Figure 1. After release from an endocrine gland, a hormone is transported to its ...
The well-known second messenger cyclic adenosine 3′-5′-monophosphate (cAMP) plays a central role in the cells response to external stimuli. While the regulation of cAMP can be controlled by a number ...
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