The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of ...
Insulin/IGF-like signaling (IIS) is one of the most prominent aging-regulatory pathways. Conserved from worms to mammals 1,2, it has critical roles in the regulation of metabolism, reproduction, ...
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