DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

DNA replication is the fundamental process by which cells duplicate their genetic material before division. Initiation occurs at defined origins where a hexameric helicase unwinds the double helix, ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

Tsukuba, Japan—Mitochondria are intracellular organelles that evolved from a bacterium belonging to Alpharoteobacteria, which was taken up as an endosymbiont by the common ancestor of eukaryotes.

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study. In a new paper published in Nature Communications, an ...

Researchers at The University of Texas Medical Branch (UTMB) have identified how a key enzyme called ATR protects DNA from breaking when cells copy damaged genetic material, a discovery that could ...

A few years ago, the advent of technology known as CRISPR was a major breakthrough in the scientific world. Developed from a derivative of the immune system of bacteria, CRISPR enables double strands ...

Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...

In 2020, Jennifer Doudna won the Nobel Prize in chemistry for her work on the CRISPR-Cas9 gene-editing technology that allows scientists to precisely modify DNA by cutting it at specific locations.

Cancer cells have ways to hide from the immune system, but there are some unique features on these dangerous cells that distinguish them from healthy cells. Scientists may have now developed a ...