Thymine metabolism in prokaryotes encompasses both de novo synthesis of deoxythymidine triphosphate (dTTP) via the reductive branch of pyrimidine biosynthesis and salvage pathways that recover ...

In prokaryotes, DNA replication initiates at a single defined origin and proceeds bidirectionally via a multiprotein replisome that unwinds the duplex and synthesises new strands. Elongation is ...

Brandt Eichman and Walter Chazin, professors of biochemistry, have worked together to provide a better understanding of how exactly DNA replication is initiated in eukaryotes. Using Vanderbilt's state ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...