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Gut microbes emerge as potential players in estrogen-driven cancers

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter ...
Nature

Endocrine disruptors reprogram hepatic metabolic and immune gene networks to promote hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and ranks as the third leading cause of cancer-related mortality worldwide 1,2,3. The burden of HCC continues to rise, ...
Nature

Calcium-Sensing Receptor Mechanisms in Endocrine Signaling

The calcium-sensing receptor (CaSR) is a class C G-protein-coupled receptor that serves as a central regulator of extracellular calcium homeostasis by modulating parathyroid hormone (PTH) secretion ...
ascopubs.org

Molecular profiling after short-term preoperative endocrine therapy to identify oestrogen receptor positive (ER+)/HER2+ early breast tumours with favourable prognosis.

Association of circulating T lymphocytes and their functional states with pathologic complete response (pCR) in breast cancer (BC). A prospective Italian study. This is an ASCO Meeting Abstract from ...
Cure Today

How Endocrine Therapy Works in ER-Positive, HER2-Negative Metastatic Breast Cancer

In this segment, Dr. Gregory Vidal explains how hormone, or endocrine, therapies work to slow or stop cancer growth in ER-positive, HER2-negative metastatic breast cancer. In this segment, Dr. Gregory ...