Blood tests, ultrasounds, and MRIs often fail to detect the earliest changes in cardiomyopathy, when fibroblasts activate and start the scarring process. Since early detection is crucial for the best ...

As society ages, the number of patients with heart failure is rapidly increasing. The progression of the disease is caused by excessive growth of fibrotic tissue in the heart, known as fibrosis. A ...

In recent years, interest has grown around two investigational peptides, BPC-157 and TB-500, proposed as part of a combined research-oriented protocol to explore tissue regeneration, angiogenesis, and ...

NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...

Piezo2 is increased in idiopathic pulmonary fibrosis (IPF). Immunohistochemistry of nonfibrotic (left) and IPF (right) lung tissue demonstrating that Piezo2 (brown staining) is strongly present in ...

Metabolic reprogramming in fibrotic lung diseases involves key metabolites like lactate, succinate, and 2-hydroxyglutarate, driving inflammation and fibroblast activation. Lactate accumulation ...

A new PET/CT imaging technique that visualizes activated fibroblasts in the heart muscle enables early detection of multiple forms of cardiomyopathy, according to research presented at the Society of ...

Fibroblast activation protein (FAP) is a serine protease, the expression of which increases with pathogenic fibroblasts in the fibrotic liver during metabolic dysfunction-associated steatohepatitis ...