After double-digit favorites went 3-1 ATS in Week 15 (the Eagles, Jags and Niners all covered spreads of at least 11 points, while Seattle narrowly avoided an upset vs. the Colts), will backing heavy favorites once again pay off this weekend?

Now, he's going up against a Jets defense that just allowed Trevor Lawrence to post six total touchdowns (five passing and one rushing), which led to the firing of defensive coordinator Steve Wilks. Shough shouldn't face much resistance this week, which could make it very hard for undrafted rookie Brady Cook to keep up in his second career start.

Hard Rock Stadium is the location where the Miami Dolphins (6-8) will attempt to defeat the Cincinnati Bengals (4-10) on Sunday. Cincinnati opens this matchup as 4.5-point favorites from Vegas oddsmakers. The total is set at 47.5.

Thunder Dan Palyo offers his top NFL sports predictions for Novig markets in Week 16. Use his recommended picks to win on Novig.

Jaxon Smith-Njigba is one of the best wideouts in the game, and our expert NFL predictions expect him to find the paint against the Indianapolis Colts.

The Pittsburgh Steelers (8-6) are en route to Ford Field on Sunday where they will try to beat the Detroit Lions (8-6). Pittsburgh opens this matchup as 7-point dogs from Vegas oddsmakers. The over-under is set at 52.

Chris Vasile breaks down his favorite NFL picks against the spread for Week 15, including the Los Angeles Rams and Denver Broncos.

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The Los Angeles Rams and Seattle Seahawks open Week 16 of NFL action with a huge NFC West showdown in primetime.

No quarterback has been forced to throw more than Jacoby Brissett over the last month, and we expect the Arizona veteran to stay busy under center on Sunday.