Nature study describes a de novo protein design and high-throughput living-cell screening platform for creating miniproteins that modulate G protein-coupled receptors (GPCRs), a major class of drug ...

The year was 2022. Chris Norn, PhD, was wrapping up his time as a postdoctoral researcher at the Institute for Protein Design (IPD) at University of Washington (UW). AlphaFold was taking the field by ...

G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to transmit signals inside the cell. These signals are transmitted primarily ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with each ...

CHICAGO--(BUSINESS WIRE)--Exicure, Inc. (Nasdaq: XCUR, “Exicure”, “the Company”), has announced the signing of a Memorandum of Understanding (MOU) with GPCR ...

The discovery of G protein-coupled receptor (GPCR) heteromers has revealed a new level of complexity in their functional characteristics. This review explores a variety of methodologies and live cell ...

New research shows how artificial intelligence, combined with advanced experimental science, can help find "hidden" and unexplored proteins in the human body and reveal what they actually do, ...

Skape Bio Launches Nature-Published Platform for AI-Designed GPCR Biotherapeutics Nature study describes a de novo protein design and high-throughput living-cell screening platform for creating ...

A computer-designed miniprotein activates a cell-surface receptor, illustrating a new approach for creating precision medicines that selectively control cell signaling. Credit: Cognition Studio, Inc.

Skape Bio and researchers at the University of Washington’s Institute for Protein Design (IPD) today announced a peer-reviewed study published in the leading international journal Nature demonstrating ...