Researchers have identified a suite of genes and regulatory elements critical to normal heart development. Their study outlines the importance of 'hub genes' in heart development. The advent of genome ...

Infants born with Down syndrome, the genetic condition caused by an extra copy of chromosome 21, or trisomy 21, are highly predisposed to congenital heart defects. It is estimated that nearly half of ...

A central paradigm in cardiac biology is the reactivation of the fetal gene programme in the adult heart in response to stress. This so-called ‘fetal gene hypothesis’ was first proposed almost 40 ...

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists—so far. A new multi-chamber organoid ...

The autonomic nervous system, which includes both the sympathetic and parasympathetic nervous systems, innervates most organs in the body and regulates numerous involuntary physiological processes, ...

A crucial new mechanism that helps explain how the heart’s major blood vessels form during early development – and how disruptions to this process can lead to serious congenital heart defects – has ...

The heartbeat is synonymous with life. It's one of the first essential functions to begin during development and to end at death. "The heart is one of the first organs to form and function during ...

Writing in Science Advances researchers of the University of Cologne describe a key mechanism that controls the decision-making process that allows human embryonic stem cells to make the heart. These ...

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far. A new multi-chamber organoid ...

New research in Sweden has produced a "blueprint" revealing how the human heart is built during prenatal development. It offers insights that could lead to improved prenatal care and new treatments ...

Long before human bone marrow takes over the task of producing blood, discrete waves of blood cell production occur in the developing embryo. Miriana Dardano, a postdoctoral researcher in Zweigerdt’s ...

In humans, a specialized mRNA translation circuit predetermines the competence for heart formation at an early stage of embryonic development, a research team at the Center for Molecular Medicine ...