Hereditary spastic paraplegia, or HSP, is a group of movement disorders that cause progressive weakness and stiffness in the legs of people with certain inherited genetic mutations. The rare ...

In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP). In addition we are developing and ...

Our research can shed light on the connection between the endoplasmic reticulum and many diseases, such as Alzheimer's disease and Hereditary spastic paraplegia.