Chromatin is composed of nucleosomes, which consist of DNA and histone proteins. The histone amino terminus has a 'tail' region that is highly conserved between species and consists of protein modules ...

In a study that takes another look at histones' origins, researchers report these proteins, known for DNA-packing, may have evolutionary roots in early life in helping to maintain the use of metals ...

The vacuolar protein sorting 75 (Vps75) histone chaperone participates in chromatin assembly and disassembly at both active and inactive genes through the preferential binding to histone H3-H4. Vps75 ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Strands of DNA wrapped around a histone. Credit: Molekuul/Science Source Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 25 (Dec. 5, 2000), pp. 13708-13713 (6 pages) The trichostatin A (TSA)-sensitive histone deacetylase (HDAC) ...

There is perhaps no more fundamental property of life than change, both with respect to personal experience and, as the basis of evolution, to the nature of biology itself. The constant genetic ...

Chromatin Immunoprecipitation Seqencing (ChIP-Seq) is a powerful tool that enables researchers to investigate and understand protein−DNA interactions and the influence these have on gene expression ...

Researchers identify hundreds of candidate histone proteins in bacteria, including one with an unusual way of binding to DNA. Now, Warnecke and colleagues are challenging the idea that these ...

The story of cancer is, largely, one of broken genes. The valiant tumor suppressor, defender of cellular integrity, maimed and enfeebled. The conniving oncogene, hyper-activated, allowed to run wild ...