Williams isn’t the only 49er destined for the Hall of Fame who could have ended up in Los Angeles. In 2022, San Francisco general manager John Lynch detailed how he won a “a 49ers-Rams tug-of-war” in getting star running back Christian McCaffrey from Carolina.

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

The San Francisco 49ers have a handful of injured starters who could return when the Los Angeles Rams visit Levi's Stadium in Week 10.

The 49ers improved to 6-3 with a Week 9 win over the Giants. See how San Francisco's NFC playoff picture and seeding shape up heading into Week 10.

After one week back at home in Los Angeles, the Rams will be on the road again in Week 10 for a pivotal matchup with the San Francisco 49ers. It’s a rematch of their Week 5 game that went into overtime, only for the 49ers to win on a field goal and subsequent fourth-down stop in the final minutes.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

The 49ers haven't had Brock Purdy since Week 4, and amid reports of his potential return Sunday against the Rams, coach Kyle Shanahan said Purdy may be dealing with the injury the rest of the year.

San Francisco 49ers fans were so prevalent at MetLife Stadium in Week 9 that the New York Giants had to switch to the silent count.

The Los Angeles Rams' offense got practically everything they wanted in their Week 9 blowout win over the New Orleans Saints.