The study, published in Diabetologia, a top journal in the field of diabetes, demonstrates that HPH-15 outperforms metformin by activating AMP-activated protein kinase (AMPK)—a critical protein ...
By screening a set of compounds for those that could disrupt FOXM1 condensates and transcriptional activity, the authors found activators of AMPK such as metformin. The AMPKα2 catalytic subunit ...