“While millions of people take metformin, its mechanism of action has remained enigmatic,” said Navdeep Chandel, senior author and professor of medicine and biochemistry at Northwestern ...

“This research significantly advances our understanding of metformin’s mechanism of action,” Chandel said. “While millions of people take metformin, understanding its exact mechanism has been a ...

is formulated to deliver the drug to the lower bowel to leverage the gut-based mechanisms of metformin action with lower plasma exposure. Met DR was assessed in two studies. Study 1 compared the ...

Using the metformin-unresponsive mice in combination with sophisticated genetic, neural, and metabolic techniques, we are exploring previously unrecognized neural mechanisms of metformin action.

Addition of bromocriptine to poorly controlled type 2 diabetic patients treated with diet alone, metformin ... antidiabetic agent has a novel mechanism of action; reduces plasma glucose ...