Adolescents and women with hirsutism have, by definition ... By contrast, therapy with low-dose flutamide (and metformin, if needed) aims at restoring a physiological state, especially in young ...

[12] For women with PCOS whose hirsutism does not decrease significantly with antiandrogen therapy, treatment with insulin-sensitizing agents, such as metformin (Glucophage) or thiazolidinedione ...