Taken together, our results suggest that metformin suppresses GRP78, a key driver of bortezomib-induced autophagy, and support the pharmacologic repositioning of metformin to enhance the anti ...

The two drugs are metformin, one of the most widely used diabetes medications, and the GLP-1 class of medications ... "a benefit of [this type of] early pharmacological intervention for adults ...

Treatment of T2DM is based on a thorough understanding of the pathophysiology involved and the targets for pharmacologic ... the biguanide metformin). The meglitinides are a new class of insulin ...