The use of iPSC-derived neurons to model human diseases like Alzheimer’s has enabled new advances. Nonetheless, a limitation of these cells is that their reprogramming resets epigenetic marks, erasing ...

Researchers have used microRNA-based direct reprogramming to generate neurons from fibroblasts, providing new insights into late-onset Alzheimer’s disease. Aging is the most significant risk factor ...

The findings, published in Nature on July 19, shed light on potential neural mechanisms involved in working memory and decision making. "Our study is a step toward thinking of the brain not in terms ...

The new model developed by Flatiron Institute researchers proposes that biological neurons have more control over their surroundings than previously thought, something that could be replicated in the ...

The spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer’s disease and frontotemporal dementia—has been studied with a model that incorporates human ...

Neuronal death is the indisputable endgame of Alzheimer’s disease, but what does the killing, and how? To try to solve the mystery, researchers have staged increasingly complex crime scenes in ...

In a recent study published in the journal Nature Neuroscience, researchers investigated the contributions of oligodendrocytes (OLs) and neurons to amyloid-β (Aβ) plaque burden in Alzheimer's disease ...

A new study by physicists and neuroscientists from the University of Chicago, Harvard and Yale describes how connectivity among neurons comes about through general principles of networking and ...