Cytochrome P450 enzymes constitute a vast and diverse superfamily of haem‐containing proteins that orchestrate a broad array of oxidative reactions. Their inherent versatility enables them to catalyse ...

Drugs are metabolized in the liver using several enzyme-catalyzed processes. These enzymes are collectively referred to as the hepatic microsomal enzyme system, and they are usually present in the ...

The cytochrome P450 (CYP) enzymes are a protein superfamily involved in the synthesis and metabolism of drugs, toxins and normal cellular components. The CYP family of enzymes have been identified in ...

Scientists have solved a 40-year-old puzzle about the mysterious process by which a critical enzyme metabolizes nutrients in foods and chemicals in drugs such as Tylenol, caffeine and opiates. The ...

Increased lipid content in the steatotic liver induces chronic endoplasmic reticulum (ER) stress, mainly via the alteration of Ca 2+ homeostasis Classic ER stress responses such as ER-associated ...

The first-ever structure of a full-length P450 enzyme has been solved. Cells use these enzymes to synthesize hormones and metabolize drugs. Chemists would like to engineer them to carry out reactions ...

Researchers have found that drug metabolism depends not only upon which enzymes are present in an individual, but also how they interact, and that can be the difference in whether a drug is safely ...

A family of nearly 3,000 artificial cytochrome P450 enzymes has been created by a California Institute of Technology team's efforts to recombine sections of three natural cytochrome P450s, a large ...

Editor’s note: This week’s Deep Dive feature focuses on human enzyme research. RESEARCH TRIANGLE PARK – It’s the biggest National Institutes of Health grant in Appalachian State University’s history, ...

Enzymes will play a crucial role as catalysts in the emerging bioeconomy of the 21 st century, says Elizabeth Gillam of the School of Chemistry and Molecular Biosciences at the University of ...