Polycystic kidney disease (PKD) is a genetic disorder marked by the growth of many fluid-filled sacs (cysts) in your kidneys. These cysts can grow to replace normal kidney tissue over time, leading to ...

Polycystic kidney disease (PKD) causes round, fluid-filled sacs called cysts to grow in your kidneys. These cysts can cause your kidneys to enlarge and function poorly. People with PKD can also ...

PKD is mainly caused by mutations in the PKD1 and PKD2 genes, affecting polycystin proteins. Disrupted signaling pathways, like cAMP and vasopressin, are major drivers of cyst growth. Tolvaptan is ...

People with autosomal dominant polycystic kidney disease (ADPKD) are at a high risk of developing kidney failure during their lives. Although there are many strategies that can be used to help reduce ...

Having PKD increases the risk of brain aneurysms. This is due to several factors, including the genetic aspects of PKD and its effect on blood pressure. Polycystic kidney disease (PKD) is a hereditary ...

A group of rare diseases called ciliopathies -- polycystic kidney disease notable among them -- emerge from defects in cilia. These are the tiny hairlike structures on the surface of almost every cell ...

Blocking the inhibition of PKD1 and PKD2 gene expression by deleting a binding site for microRNAs hindered the formation and growth of kidney cysts in autosomal dominant polycystic kidney disease ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Autosomal dominant polycystic kidney disease did not ...

SAN DIEGO, California — Treatment with tolvaptan, a currently marketed drug, can slow the progression of autosomal dominant polycystic kidney disease (ADPKD). Although not currently approved for this ...

"Groups such as the American College of Medical Genetics and Genomics can use this study to help determine whether PKD1 and PKD2 should be considered in future recommendations for reporting of ...

Chronic pain is a common challenge when you have autosomal dominant polycystic kidney disease (ADPKD). But there are many treatment options to help you manage your pain and other symptoms so you can ...