Early in Alzheimer’s disease, phospho groups modify tau at multiple sites. What controls this process? In the July 6 Science Advances, researchers led by Arne Ittner at Flinders University, Adelaide, ...

In Alzheimer’s disease and other dementias, a protein called tau can pile up inside brain cells and form toxic clumps. Those clumps help drive memory loss and other symptoms. Yet some neurons seem to ...

For anti-tau antibodies, researchers are still learning what strategies work best. Sometimes, however, the lessons are unclear. Case in point: Two new papers conflict about which antibody isotype ...

Brain section from mouse carrying the dementia-causing P301S mutation in human tau shows accumulation of tau neurofibrillary tangles (in dark brown, left). When Nuak1 levels are decreased by 50 ...

The irregular buildup of tau protein in the brain can form “tangles,” which researchers link to several brain disorders, including Alzheimer’s disease. This may have implications for detecting and ...