Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), shedding light on potential therapeutic targets for combating tumor progression, ...

Ubiquitin is a small protein consisting of 76 amino acids that binds to lysine residues of substrates, usually by a combination of three enzymes: a ubiquitin-activating enzyme (E1, two types), a ...

Researchers from the Institute of Science Tokyo have used a Drosophila model to understand the underlying mechanism of T-tubule formation. The results show the involvement of LUBEL, an E3 ubiquitin ...