Hemostasis or stoppage of bleeding occurs in three steps blood vessel constriction, platelet plug formation and blood clotting (coagulation). The blood vessel constricts to allow less blood to be ...

Ibuprofen might have advantages over indomethacin, when used to effectuate closure of a neonate's patent ductus arteriosus (PDA). Several previous studies indicate that platelet plug formation is ...

Dr. Woulfe's research interests focus primarily on the intracellular signaling mechanisms of platelet activation and how signaling in platelets contributes to thrombosis in vivo. Agonists that extend ...

That work also suggested that mice lacking the CIB1 were still able to form a platelet plug, suggesting that this gene was involved only in the process of thrombus formation.

The underlying disease process often results in endothelial damage, which causes the release of cytokines such as interleukins 1, 6, and 8, platelet activating factor, and tumor necrosis factor.

Figure 1: Formation of a platelet plug at sites of blood-vessel injury. Top, circulating platelets are maintained in an inactive state by prostacyclin and nitric oxide, released by endothelial cells.