Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

The treatment of long benign oesophageal strictures remains a clinical challenge. We present a novel endoscopic technique ...

Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance ...

Background Endoscopic procedures are a notable source of medical waste, contributing significantly to environmental pollution ...

We thank Dr Yang and colleagues for their interest in the HELIOS trial and their thoughtful appraisal of our findings.1 2 Yang et al highlight the possibility that heterogeneity in endoscopist ...

Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ-PKAc fusion oncoprotein. However, the underlying mechanism of DNAJ-PKAc’s ...

Background Injured or reactive biliary epithelial cells participate in most chronic liver injuries in a process referred to as ductular reaction, which involves multicellular interactions with marked ...

Background IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A ...

4 Department of Pharmacology and Toxicology, Raymond Poincaré Hospital, AP-HP, Garches; Centre for Research in Epidemiology and Population Health (CESP), Team MOODS, Inserm UMRS 1018, ...

Correspondence to Professor Nigel W Bunnett, Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010, USA; nwb2{at}nyu.edu Objective The effectiveness of ...

Background Determining optimal management of colorectal polyps in patients with limited life expectancy of under 10 years can be difficult, due to challenges balancing an uncertain natural history of ...

Correspondence to Dr M Lisa Zhang, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA; mlzhang{at}mgh.harvard.edu Objective Elevated pancreatic cyst fluid ...