The San Francisco 49ers will be without star running back Christian McCaffrey for a while. The 49ers are placing McCaffrey on injured reserve, a person familiar with the situation told USA TODAY ...

The San Francisco 49ers picked up their first loss of the season, falling 23-17 to the Minnesota Vikings in Week 2. A special teams error, two turnovers (interception and fumble) and two turnovers ...

Another star player on the 49ers has suffered a calf strain that will hold him out for a "couple weeks" per head coach Kyle Shanahan. The loss to the Minnesota Vikings is getting worse for the San ...

The San Francisco 49ers take their 1-0 record to the road against the Minnesota Vikings on Sunday. San Francisco easily took care of the Aaron Rodgers and the New York Jets at home in the season ...

A pressure-packed season for the San Francisco 49ers is already ratcheting up severely. The 49ers dropped a game to the upstart Minnesota Vikings for the second straight year on Sunday ...

The 49ers reportedly checked in on multiple potential replacements for Brandon Aiyuk in the wake of the uncertainty surrounding the wide receiver this offseason. Before San Francisco ended their ...

The San Francisco 49ers have one of the most well-built rosters in football. San Francisco made a run to the Super Bowl last season, although it ended up losing to the Kansas City Chiefs.

LATEST Sept. 14, 10:30 a.m. The San Francisco 49ers are placing Christian McCaffrey on injured reserve on Saturday, according to multiple reports. ESPN’s Adam Schefter and NFL Network’s Ian ...

The upcoming clash between the Minnesota Vikings and the San Francisco 49ers at U.S. Bank Stadium marks a crucial early test for the Vikings. As both teams enter the game coming off season-opening ...