There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic–pituitary–adrenal (HPA) axis. However, several promising HPA-modulating drugs ...

Adrenal tumors are a heterogeneous group of tumors characterized by diverse biology and clinical courses. They may be associated with high malignant potential and/or hormonal activity, leading to ...

Gallot D; Marceau G; Coste K; Hadden H; Robert-Gnansia E; Laurichesse H; Déchelotte PJ; Labbé A; Dastugue B; Lémery D; Sapin V Congenital ... a retinoid-signaling pathway disruption in the ...

Tissue factor pathway inhibitor antagonist To prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years and older with hemophilia A (congenital factor VIII ...