Frontiers

IFNγ-mediated suppression of alternative NF-κB in tumor-resident myeloid cells promotes selective recruitment of cytotoxic but not regulatory T cells

Immunotherapy is currently effective in less than half of patients with solid tumors, and most responders develop secondary progression. High infiltration of the tumor microenvironment (TME) with CD8 ...
Cancer Research

Tunneling CARs: Increasing CAR T-Cell Tumor Infiltration through the Overexpression of MMP-7 and Osteopontin-b

1Graduate Program in Immunology and Microbiology, Baylor College of Medicine, Houston, Texas. 2Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital, and Houston ...
Cancer Research

Multiplexed imaging mass cytometry reveals tumor-immune microenvironment-dependent hormone receptor expression in adult type ovarian granulosa cell tumors

The University of Texas MD Anderson Cancer Center, Houston, Texas, United States ...
Frontiers

Acupoint Application Improves IVF Outcomes and Rescues Granulosa Cell Steroid Metabolic Dysregulation in Ovarian Endometriosis

1 Reproductive Center of Integrated Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China 2 Binzhou Hospital of Traditional Chinese Medicine, BinZhou, ...
BioSpace

Novocure to Present Final Results from the Pivotal Phase 3 METIS Trial of its Tumor Treating Fields (TTFields) Therapy for Brain Metastases from Non-Small Cell Lung Cancer at ...

METIS trial achieved its primary endpoint, showing a statistically significant delay in time to intracranial progression in patients receiving TTFields therapy and best supportive care following ...