Structural brain changes in the medial temporal lobe found up to 15 years before Alzheimer’s symptoms in people with Down syndrome, aiding early diagnosis.

MRI-based structural imaging has become an integral component of the clinical assessment of patients with suspected Alzheimer disease (AD), and atrophy of medial temporal structures is now ...

A study led by the Sant Pau Research Institute (IR Sant Pau) has succeeded in describing, for the first time in detail, the structural evolution of the medial temporal lobe (MTL) regions across the ...

Background and Purpose— Medial temporal lobe atrophy (MTA) is a hallmark of Alzheimer disease (AD). Its progression is often seen during the course of AD, but its frequency and risk factors remain ...

METHODS Medial temporal lobe atrophy in 143 patients was visually rated from hard copies, using a 0–4 rating scale and a comparison was made with the volumes (cm3) of the medial temporal lobe as ...

Objective: To assess the associations of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) with cognitive function in a large group of independently functioning elderly people ...

These existing measures also heavily rely on verbal tasks, which can be problematic when exploring medial temporal lobe functioning. For example, such tasks have limited utility in the context of ...

Kuzniecky et al. expressed concerns about the differences between normal aging-related cerebral atrophy observed in our healthy controls and those reported in a previous study, which showed ...

USC researchers have found a promising new brain scan marker that could better detect Alzheimer’s risk — but only for some.

The team used a special type of brain scan called tau PET, which tracks a protein known as tau that builds up in the brain ...

The predilection of HSV-1 for the orbital surface of the frontal lobe and medial surface of the temporal lobe indicates that virus might spread from olfactory mucosa through the cribiform plate of ...

As neurons die in those regions, the lobes atrophy or shrink. Unusual behaviors, emotional problems, trouble communicating, difficulty walking, or issues at work can occur.