Objective To confirm that metformin prevents flares in patients with SLE with low disease activity, we performed a post hoc analysis combining our previous two randomised trials.Methods Post hoc ...

Over 3 weeks, the metformin dose was increased to 1000mg before breakfast and 500mg before dinner, after which the dosage was maintained constant to the end of the 8-week double-blind period.

Conclusions Metformin and sitagliptin were both effective in reducing fasting glucose and HbA1c levels in patients with recent TIA or minor ischaemic stroke and IGT. However, the reduction of glucose ...

Introduction Gestational diabetes mellitus (GDM) is a common disorder of pregnancy and contributes to adverse pregnancy outcomes. Metformin is often used for the prevention and management of GDM; ...

We already know quite a lot about metformin. It's been around for decades, and is considered a gerotherapeutic: a drug able to slow down various aging processes in the body. For example, it's been ...

Oxypurinol is a metabolite of allopurinol, a drug used to treat gout, and metformin is a first-line treatment for type 2 diabetes. Both oxypurinol and metformin enter the wastewater treatment plants ...