Investigators exploring the genetic profile of a small number of adult ovarian granulosa cell tumors found that each had a specific missense point mutation in FOXL2 (402C > G [C134W]), a gene that had ...

High-grade serous ovarian cancer is the most common and aggressive form of ovarian cancer and often becomes resistant to ...

Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, ...

Examination of Japanese cases of gynecological cancer offers a better understanding of the profile of a rare ovarian tumor and could change treatment guidelines. Ovarian granulosa cell tumors are a ...

This study is led by Prof. Yang Yu (Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital). Age-related female infertility and increase of the ...

Patterns of ovarian cancer care in an elderly population in Australia: A prospective cohort study from the National Gynaecology Oncology Registry (NGOR). This is an ASCO Meeting Abstract from the 2023 ...

Abstract Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen. Patients ...

Mature egg cells, or oocytes, are essential for fertilization in assisted reproductive technologies. However, some 'denuded' oocytes, or those lacking the protective granulosa cell layer, fail to ...

Premature ovarian insufficiency (POI) affects 1–3% of women and has limited treatment options. Researchers report that ...