A 23-year-old woman presented with a 7 cm right multicystic mass in the ovary, which corresponded microscopically to an unusual lesion consisting of a multifocal granulosa cell tumor with ...

Ovarian granulosa cell tumors are a rare type of ovarian cancer that affect the ovaries and fallopian tubes, and can extend further into the pelvis and lymph nodes.

Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen. Patients may ...

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Figure 4: Low-power photomicrograph of granulosa cell tumor from the corn snake in Figure 1. Reports of tumors in corn snakes are rare. A survey of snakes at the National Zoological Park ...

Ovarian follicles are the basic functional unit of the ovary and consist of an oocyte, the immature egg, which is surrounded by granulosa cells. Besides being crucial to the development of ...

Forkhead box protein L2 (FOXL2) is a protein involved in ovary development and maintenance, among other functions. Mutations in its gene are involved in ovarian failure and granulosa cell tumors, ...

These findings form the basis for the GRACED study, a study protocol in which granulosa cell tumor patients receive treatment based on the laboratory response of their own tumor cells. This represents ...

While most ovarian research focuses on the development of oocytes and surrounding granulosa cells, little is known about the cellular composition of ovarian stroma cells.

Granulosa cell tumors are a well-defined ovarian cancer subtype, responsible for 2-5% of ovarian malignancies with an annual incidence of 0.6-1.0 per 100.000 women worldwide.