However, with no efficient treatments directly targeting cardiac fibrosis, it presents an ever‐growing clinical challenge. 9, 10 The fibrotic process is mediated by activation of cardiac fibroblasts ...

Background Smoking has been considered an important risk factor for idiopathic pulmonary fibrosis (IPF) incidence. However, there are no population-based large-scale studies demonstrating the effects ...

The study uncovers how ovarian ECM tropism influences endometriotic cell adhesion, paving the way for novel strategies to ...

A recent hospitalization reminded me that my strength to fight cystic fibrosis is deeply rooted in my Filipino heritage and the unwavering support of my family.

Nerandomilast significantly reduces the decline in forced vital capacity in adults with progressive pulmonary fibrosis over 52 weeks, thereby slowing the progression of the condition.

Pulmonary fibrosis is a feared complication of respiratory infections. We found that among survivors of severe COVID-19, 20% of non-mechanically ventilated and 72% of mechanically ventilated ...

Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), are major leading causes of death worldwide and are generally associated with poor ...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition and irreversible lung damage. A key driver of ...

Liver fibrosis is characterised by the excessive deposition of extracellular matrix (ECM) in response to chronic and sustained liver damage, triggering a prolonged wound healing response. The ...

Objective Extracellular matrix protein 1 (ECM1) serves as a gatekeeper of hepatic fibrosis by maintaining transforming growth factor-β1 (TGF-β1) in its latent form. ECM1 knockout (KO) causes latent (L ...

Applying spatial profiling, we identify a fibro-collagenous and immune-infiltrated stromal phenotype [stromal cluster (SC) 2] characterized by increased cancer-associated fibroblasts, memory B cells, ...