Objective To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). Design 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled ...

Importance The role of intravenous short-acting beta-2 agonist (SABA) in acute asthma in childhood is unclear. Objectives To assess the safety and efficacy of intravenous SABA versus placebo for acute ...

Importance Evidence regarding second-line treatment for severe asthma is limited. Objectives To evaluate the safety and efficacy of intravenous aminophylline, intravenous short-acting beta agonist ...

A previously healthy 14-year-old girl presented with right-sided weakness and dysarthria. Two weeks earlier, she had presented with an isolated episode of atraumatic, self-resolving bruising over her ...

We encounter, occasionally, parents who are incapable of making medical decisions on behalf of their incompetent or incapacitated children. When the incapable parent is themselves a child; measures ...

Background The gold standard of paediatric obstructive sleep apnoea syndrome (OSAS) diagnosis is overnight polysomnography (PSG). Validated screening methods for paediatric OSAS are limited.

Nirsevimab, a long-acting monoclonal antibody, was introduced last season (2023–2024) in some countries with the aim of reducing the burden of disease caused by respiratory syncytial virus (RSV) in ...

Background/aim Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are rare imprinting disorders caused by the aberrant expression of 15q11.2-q13 imprinted genes. Due to their rarity, data on ...

Objective To validate a short parent-reported outcome (PRO) questionnaire in young boys with conditions affecting sex development (PRO-CSD). Design Consecutive sample cross-sectional study. Setting A ...

Objectives To evaluate the appropriateness of the American Academy of Pediatrics’ (AAP) recommendation to no longer collect a urine culture (UC) in febrile infants ≥21 days old with negative ...

A 3-week-old infant is diagnosed with tuberous sclerosis complex (TSC) after cardiac rhabdomyomas are detected on prenatal ultrasound and a pathogenic variant in TSC2 is confirmed postnatally through ...

Objective It is important to detect reduced peripheral perfusion due to hypovolaemia early before it progresses to shock. Capillary refill time (CRT) and manual palpation for peripheral coolness are ...