Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component (Block, Winfield et al. 1975, Deapen, Escalante et al. 1992, Alarcon- Segovia, ...

Purpose Tertiary lymphoid structures (TLS) are organized aggregation of immune cells at sites of inflammation. The development of TLS in autoimmune settings indicate that they may be sites for both ...

Atherosclerosis cardiovascular disease (ASCVD)-related mortality is higher in patients with lupus nephritis (LN) compared with those without nephritis (11.7 vs 3.6 per 100 patient-years).1 Accelerated ...

Background Pre-clinical mouse models are invaluable tools to investigate the mechanisms driving systemic lupus erythematosus (SLE) and identify therapeutic targets to treat human disease. The BXSB.Yaa ...