Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component (Block, Winfield et al. 1975, Deapen, Escalante et al. 1992, Alarcon- Segovia, ...

Objective This study aims to evaluate the role of antiphospholipid antibodies (aPLs) in patients with SLE with heart valve ...

Purpose Tertiary lymphoid structures (TLS) are organized aggregation of immune cells at sites of inflammation. The development of TLS in autoimmune settings indicate that they may be sites for both ...

Atherosclerosis cardiovascular disease (ASCVD)-related mortality is higher in patients with lupus nephritis (LN) compared with those without nephritis (11.7 vs 3.6 per 100 patient-years).1 Accelerated ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Background Pre-clinical mouse models are invaluable tools to investigate the mechanisms driving systemic lupus erythematosus (SLE) and identify therapeutic targets to treat human disease. The BXSB.Yaa ...

Purpose TLR7 and TLR8 (TLR7/8) are members of the Toll-Like Receptor family that recognize single strand RNA. Activation of TLR7/8 within immune cells elevates pro-inflammatory cytokines and type ...

Introduction Double-stranded-DNA antibodies (antiDNAds) are the most frequently detected serological markers in patients with Systemic Lupus Erythematosus (SLE). In clinical practice, it is usually ...

Background Systemic lupus erythematosus (SLE) is a chronic, complex autoimmune disease characterized by pathogenic autoantibodies and tissue damage to multiple organ systems. Nipocalimab is a novel ...

Objectives This study aimed to investigate hemostatic variables in pregnant patients with Systemic Lupus Erythematosus (SLE) in relation to preeclampsia (PE), antiphospholipid antibody (aPL) status ...

Background Pathogenic extrafollicular double negative 2 (DN2) B cells in SLE have a phenotype of IgD − CD27 − Tbet + CD11c +, and are the precursor of ribonuclear protein (RNP) autoantibody producing ...

Background Systemic Lupus Erythematosus (SLE) is a prototypic, systemic autoimmune disease that can affect many organs. Current treatment of SLE is largely empirical, while the existing ...