The Arizona Cardinals close out the season in Week 18 at home facing the San Francisco 49ers for the second time. The Cardinals won the first meeting in Week 5 in Santa Clara 24-23 on a last-minute field goal by kicker Chad Ryland,

See who's in and who's out for the Week 18 matchup between the Arizona Cardinals and San Francisco 49ers on January 5, 2025.

See what Kyle Shanahan, Joshua Dobbs, Jonathan Gannon and Kyler Murray had to say following the Week 18 contest.