The 49ers fell out of first place in the NFC West last week, losing 26-15 on the road to the Houston Texans as 3-point ...

The Old Dominion football team played its most complete game in a month, and blew past ULM, 31-6, Saturday afternoon to become bowl eligible for the ...

The San Francisco 49ers head to the New Jersey Meadowlands to face the New York Giants for NFL Week 9, and there are several ...

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -151 money line favorites (risk ...

Rivalry week begins Thursday in North Carolina. Get Thursday’s NC scores, coverage, Friday’s schedule, Talking Preps postgame ...

TheSan Francisco 49ers are looking to bolster their defense. With three days left before the trade deadline, they acquired DL ...

The San Francisco 49ers and general manager John Lynch continue to work the phones ahead of the NFL trade deadline on Nov. 4.

The 49ers (5-3) and the Giants (2-6) renew a storied rivalry Sunday at MetLife Stadium as each cope with the losses of big-time stars.

The San Francisco 49ers are one of the most banged teams in the NFL right now, with a question mark at quarterback every week.

Purdy is listed as questionable after limited participation in practice this week. Shanahan said that Purdy could be available in an emergency role behind Jones and Adrian Martine ...

The 5-3 San Francisco 49ers head to MetLife Stadium to face the reeling New York Giants on Sunday, November 2. My top NFL picks and 49ers vs. Giants predictions are calling for San Fran to take care ...

Sunday, 1 p.m. EST, CBS. BetMGM line: 49ers by 2 1/2. Against the spread: 49ers 4-4, Giants 4-4. Series record: 49ers lead 22-21. Last meeti ...