9 Therefore, physiological functions under circadian control include the sleep-wake cycle, heart rate, blood pressure, body temperature, as well as endocrine gland regulation (ie, gonadal and adrenal ...

There are sufficient arguments to suggest that insulin excess may be a factor responsible for alteration of adrenal steroidogenesis leading to increased dehydroepiandrosterone sulfate blood levels.

The role of insulin in the regulation of enzymes involved in adrenal steroidogenesis has been postulated, although much remains to be investigated, since not all women with PCOS show evidence of ...