It's the regular season, and the game is at Highmark Stadium, so the Buffalo Bills must have the edge. On the other hand, it's the Kansas City Chiefs and in big games they seem to always find a way to break the hearts of Bills Mafia.

While Josh Allen and Joe Brady seem unconcerned about the Bills' passing game, there are clear issues, and they track back to the wide receiver group.

Ahead of the contest against the Kansas City Chiefs, the Buffalo Bills will be shorthanded. Defensive tackle DaQuan Jones, receiver Josh Palmer, and linebacker Shaq Thompson have all been ruled out, a big blow for both sides of the football.

Kansas City has beaten Buffalo in four of the last five postseasons, but the Philadelphia Eagles dethroned the Chiefs in the Super Bowl by harassing quarterback Patrick Mahomes. Philadelphia's defensive line was dominant and generated pressure without blitzing. Mahomes was sacked six times and threw two interceptions in Super Bowl 59.

Buffalo Bills' running back James Cook is earning every bit of his new contract with a historical seven-game start to the season.

The Bills need to make two key trades if they are going to have a chance to fulfill their championship aspirations

Defensive tackle Larry Ogunjobi and defensive end Michael Hoecht are back from six-game suspensions to start the season for violating the NFL’s policy performance-enhancing drugs (PED) policy. Both were added to the 53-man roster on Tuesday and have yet to debut for Buffalo after signing as free agents this offseason.

The Carolina Panthers had a three-game winning streak going into today's game against the Buffalo Bills. It didn't take long for reality to come crashing down on any hopes of an upset to extend that streak to four, though. The Bills dominated the Panthers from the opening kickoff to the last whistle, ending in a 40-9 victory for the visitors.