The CEMIP (cell migration–inducing protein) exhibits extremely high expression levels in smooth muscle tissues. However, whether CEMIP modulates the contractile phenotype of vascular smooth muscle ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein Kinase A (PKA) is regulated spatially ...

Mpox virus (MPXV) F8–A22–E4 polymerase holoenzyme is responsible for the accurate replication of the viral genome. Unlike other DNA polymerases, MPXV polymerase holoenzyme harbors the multifunctional ...

Recent studies show that hyperactivation of mTOR (mammalian target of rapamycin) signaling plays a causal role in the development of thoracic aortic aneurysm and dissection. Modulation of PP2A ...

ABSTRACT: Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key regulator of heart function. While some CaMKII activity is beneficial, excessive, or persistent, CaMKII can lead to heart ...

This study presents the cryo-EM structures of two human biotin-dependent mitochondria carboxylases involved in various biological pathways, including the metabolism of certain amino acids, cholesterol ...

Ceramide synthases (CerS) catalyze ceramide formation via N‐acylation of a sphingoid base with a fatty acyl‐CoA and are attractive drug targets for treating numerous metabolic diseases and cancers.

The dodecameric protein kinase CaMKII is expressed throughout the body. The alpha isoform is responsible for synaptic plasticity and participates in memory through its phosphorylation of synaptic ...

aDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, CB2 0AH, UK The tauopathies are a diverse group of neurodegenerative diseases that are defined by the misfolding of tau—a ...

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus. The ...