Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.

The distinct population of endothelial cells that line blood vessels in the insulin-producing "islets" of the human pancreas ...

Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...

JMU scientists studied insulin-producing cells in fruit flies, finding that secretion is influenced by gut hormones, ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Diabetes, as defined by the World Health Organization, represents a collection of metabolic diseases characterized primarily by hyperglycemia, which can ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

Mitochondria play a crucial role in cellular energy production, and their dysfunction has long been linked to metabolic ...

If insulin can’t get out of blood vessels, it can’t act in its target tissues. “Endothelial cells are full of insulin ...

Type 2 diabetes is a condition where the body cannot produce enough insulin or does not use insulin effectively. Insulin is a ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...