“While millions of people take metformin, its mechanism of action has remained enigmatic,” said Navdeep Chandel, senior author and professor of medicine and biochemistry at Northwestern ...

Using the metformin-unresponsive mice in combination with sophisticated genetic, neural, and metabolic techniques, we are exploring previously unrecognized neural mechanisms of metformin action.

Addition of bromocriptine to poorly controlled type 2 diabetic patients treated with diet alone, metformin ... antidiabetic agent has a novel mechanism of action; reduces plasma glucose ...