Our granulosa-like cells have transcriptomes similar to human fetal ovarian cells and recapitulate key ovarian phenotypes including follicle formation and steroidogenesis.

A 23-year-old woman presented with a 7 cm right multicystic mass in the ovary, which corresponded microscopically to an unusual lesion consisting of a multifocal granulosa cell tumor with ...

Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen. Patients may ...

A research team has uncovered a novel molecular pathway linking oxidative stress to cell death in pig ovarian follicles, ...

Ovarian granulosa cell tumors are a rare type of ovarian cancer that affect the ovaries and fallopian tubes, and can extend further into the pelvis and lymph nodes.

The scientists compared 2,601 ovarian cells from young and old non-human primates, and identified gene activity patterns for every type of primate ovarian cell including ooctyes and granulosa ...

Primordial germ cells (PGCs) migrate to the developing gonads and proliferate. Gonadal somatic cells differentiate into ovarian stroma, granulosa, and theca cells.

The majority of stromal cell tumors of the ovary are either granulosa cell or theca cell, and account for less than 3% of ovarian neoplasms. Given that theca cell tumors are benign, we will focus ...

Juvenile granulosa-cell tumors account for only 2 to 5% of all ovarian tumors, but they are the most common malignant sex cord–stromal tumors of the ovary in adolescents, occurring at a mean age ...

While most ovarian research focuses on the development of oocytes and surrounding granulosa cells, little is known about the cellular composition of ovarian stroma cells.