Tropical Cyclone Alfred is expected to cross the south-east Queensland coast later this week, bringing significant wind, rain and coastal impacts.

Brisbane's ferries have been moved to safety and their Moreton Bay islands counterparts will soon follow suit as Cyclone Alfred prepares to make an expected sharp curve towards south-east Queensland.

Cyclone Alfred is heading towards the Australian coast, bringing destructive winds and heavy rain and prompting calls for residents to take the threat seriously.

Acting mayor Donna Gates says tropical cyclone Alfred "might be the most significant system" for the Gold Coast since 1954.

Tropical Cyclone Alfred is expected to cross the southeast Queensland coast late this Thursday as a Category 2 storm. The last tropical cyclone to make landfall in the region was ex-Tropical Cyclone Zoe in 1974, half a century ago.

Millions of residents along Australia’s east coast are on high alert for the arrival of Tropical Cyclone Alfred.

It will be the first time the south-east has been in the direct firing line of a tropical cyclone in several decades.

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Residents are remaining alert with Tropical Cyclone Alfred currently tracking above the Coral Sea around 450 kilometres north-east of Brisbane.