Importance The role of intravenous aminophylline in acute asthma in childhood is unclear. Objectives To assess the safety and efficacy of intravenous aminophylline for asthma in children. Methods From ...

Background: Difficulty falling asleep (prolonged sleep latency) is a frequently reported problem in school-aged children. Aims: This study aimed to describe the distribution of sleep latency and ...

Attention deficit hyperactivity disorder (ADHD) affects around 1–3% of children. There is a high level of comorbidity with developmental and learning problems as well as with a variety of psychiatric ...

Objective To report the diagnostic test accuracy of dipstick urinalysis for the detection of urinary tract infections (UTIs) in febrile infants aged 90 days or less attending the emergency department ...

Objective Impaired fetal and infant growth may cause alterations in developmental programming of the hypothalamic–pituitary–gonadal axis and subsequently pubertal development. We aimed to assess ...

SMA is a motor neuron disease characterised by generalised muscle atrophy and weakness. It is caused by the dysfunction and eventual death of motor neurons, due to deletions of SMN1 in 95% of patients ...

Objective The β2-agonists such as salbutamol are the mainstay of asthma management. Pharmacokinetic–pharmacodynamic (PKPD) models to guide paediatric dosing are lacking. We explored the relationship ...

Method Data was collected anonymously from students in the UK (n=56) and India (n=75) using a standardised questionnaire addressing sleep patterns, sleep hygiene habits, and knowledge regarding the ...

Objectives One in three children in England have Special Educational Needs (SEN) indicated at least once during school. We describe variation across neurodevelopmental conditions and in unaffected ...

Introduction More than half of all drugs are still prescribed off-label to children. To support off-label dosing, pharmacokinetic (PK) data are needed. Physiologically-based pharmacokinetic (PBPK) ...

Aim There is an increased use of Hormonal Contraceptives (HCs) in female adolescents, during a period of growth, development and hormonal changes.1 2 Due to the limited long-term safety data available ...

Background and Objectives Prolonged neonatal jaundice is defined as jaundice persisting in a term neonate at 14 days and a preterm neonate at 21 days of age. Prolonged neonatal jaundice is most ...