Estriol: The “Beta” Estrogen Your Body Might Be Missing If you’re on estradiol-only HRT but still dealing with dryness, burning, urinary urgency, or recurrent UTIs… you might be missing the benefits of ER-β activation. Estriol binds ER-β far more than ER-α, targeting tissues like the vagina, urethra, bladder trigone—and even certain brain and immune cells—while being gentler on ER-α–rich tissues like the breast and uterus. What the research shows: • NEJM trial: Vaginal estriol restored Lactobaci
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