GABA B receptor modulation of excitatory and inhibitory synaptic transmission onto rat CA3 hippocampal interneurons, The Journal of Physiology | DeepDyve
GABA B receptor modulation of excitatory and inhibitory synaptic …
Dec 16, 2014
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The GABA-B receptor functions as a neuronal inhibitor, distinct from its counterpart, the GABA-A receptor. It operates as a G-protein-coupled receptor (GPCR), meaning that upon activation, it initiates a cellular signaling cascade rather than acting as a direct ion channel. When a signal molecule binds, the receptor releases its associated G-protein. The G-beta-gamma subunit then travels through the cell to activate a specific type of potassium channel called GIRK (G-protein-gated inwardly recti
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The GABA-A receptor is a protein complex made of five subunits that acts as the brain's main brake, receiving inhibitory signals from neurons. When the neurotransmitter GABA binds, it opens a channel, allowing chloride ions to flow into the cell and quiet down its electrical activity. | Ribosome Studio
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