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Pancreatic cancer is one of the deadliest cancers, with a five-year survival rate of less than 10%. Unlike many other cancers, which are often detected early and treated successfully, pancreatic cancer is usually diagnosed at an advanced stage when treatment options are limited. This is partly because of its dense, fibrotic barrier. A stiff matrix of collagen and connective tissue surrounds cancer cells, creating a scar-like shell, known as the tumor stroma, that physically blocks drugs from pen
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