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Cholelithiasis ( Gallstones): Pathogenesis & Morphology
Gallstones are formed from constituents of the bile ( cholesterol, bile pigments and calcium salts).Cholesterol is rendered soluble in bile by aggregation with bile salts. When cholesterol concentrations exceed the solubilizing capacity of bile (supersaturation), cholesterol can no longer remain dispersed and nucleates into crystals. Pigment ...
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